Fractional photothermolysis laser treatment of male pattern hair loss.
نویسندگان
چکیده
BACKGROUND Various trials have been conducted on the management of male pattern hair loss (MPHL). A variety of laser and light sources have been used for the treatment of MPHL. OBJECTIVE To understand the effects of a 1,550-nm fractional erbium-glass laser on the hair cycle in an alopecia mouse model and to study the clinical effects of the same laser used as treatment for MPHL. MATERIALS AND METHODS Irradiation was applied to the shaved skin of C3H/HeN mice using various energy and density settings and varied irradiation intervals. In a clinical pilot study involving human subjects, 20 participants were treated over five sessions at 2-week intervals. A fractional photothermolysis laser was used at the energy of 5 mJ and a total density of 300 spots/cm(2). RESULTS In the animal study, the hair stimulation effects were dependent upon the energy level, density, and irradiation interval. The anagen conversion of hair and the increase in Wnt 5a, β-catenin signals were observed. In the human pilot study, incremental improvements in hair density and growth rate were observed. CONCLUSIONS This pilot study showed that a 1,550-nm fractional erbium-glass laser might induce hair growth, but more intensive studies are required to clarify the clinical applications of this treatment.
منابع مشابه
Evaluation of patient satisfaction after treatment with the alexandrite laser for hirsutism
Background: Laser treatment is a rapid, non-invasive procedure for long-term hair removal. Lasers operate based on the principle of selective photothermolysis and target melanin in the hair follicle. We intend to determine the level of hirsute patient satisfaction with the alexandrite laser hair removal procedure.Methods: In this cross-sectional study 82 hirsute patient...
متن کاملA 2940 nm fractional photothermolysis laser in the treatment of acne scarring: a pilot study in China.
OBJECTIVE To evaluate the efficacy and safety of a 2940 nm fractional photothermolysis laser in the treatment of acne scarring in Chinese people. METHODS Twenty-six patients with moderate-to-severe atrophic scarring were treated with a 2940 nm-wavelength fractional photothermolysis laser. RESULTS All patients had encouraging results. Both skin elasticity and moisture content increased signi...
متن کاملV36i4 Saedi.indd
In recent decades, there has been a revolution in energy-based treatment options for skin scarring, rejuvenation, and tightening. One of the most promising developments has been the introduction of fractional photothermolysis, developed by Anderson and Manstein in 2004. Fractionated systems deliver laser energy in a grid-like pattern, creating microscopic columns of ablative and/or coagulative ...
متن کاملFractional photothermolysis for the treatment of surgical scars.
BACKGROUND Surgical scars are a challenging condition to treat. Fractional photothermolysis provides a promising new modality for treatment. CASE REPORT A 55-year-old white female patient with a surgical scar on the chin was treated with fractional photothermolysis (1550 nm Fraxel SR laser). A single treatment session was performed at pulse energy of 8 mJ (MTZ) and a final density of 2000 MTZ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]
دوره 37 1 شماره
صفحات -
تاریخ انتشار 2011